Fisetin, a natural flavonoid commonly found in Cotinus coggygria, has been identified as a powerful anti-aging agent. According to recent studies, Fisetin has been found to kill senescent cells, i.e. cells that have stopped dividing due to age or damage, which accumulate in the body and cause inflammation, tissue dysfunction and ultimately, aging.

  Senescent cells secrete harmful molecules that damage tissues and cause chronic diseases such as cancer, arthritis, and Alzheimer's disease. Fisetin has been shown to selectively eliminate these cells by inducing apoptosis, i.e. programmed cell death, in senescent cells without affecting healthy cells. This leads to improved tissue function, reduced inflammation and enhanced cellular metabolism, which ultimately delays the aging process and extends lifespan.

  In addition, Fisetin has been found to activate several longevity pathways, such as sirtuins, AMPK, and mTOR, which regulate cellular stress responses, energy production, and cell division. By activating these pathways, Fisetin enhances the body's resilience to stress, promotes cellular repair and regeneration, and maintains a healthy balance between cell growth and death, which leads to improved health and longer lifespan.

  Furthermore, Fisetin has been shown to protect against age-related diseases by preventing oxidative stress, DNA damage, and inflammation. It has been found to scavenge free radicals, increase antioxidant defenses, and reduce pro-inflammatory cytokines, which are known to play a crucial role in chronic diseases such as cardiovascular disease, diabetes, and neurodegenerative disorders.

  Overall, Fisetin emerges as a promising natural compound with powerful anti-aging effects. Its ability to eliminate senescent cells, activate longevity pathways, and protect against age-related diseases makes it an attractive candidate for developing new anti-aging drugs and supplements. However, more research is needed to determine its optimal dosage, safety, and efficacy in humans.